57 SINCE REPRODUCING WITHOUT WOMEN?

57 SINCE REPRODUCING WITHOUT WOMEN?
A trillion of trillions of years before
After the murder of Fratedes, Nimis it(he,she) followed(continued) the fingerprint to M and L, it(he,she) knew that the new Thaumasios was the only(unique) human being with the aptitude to construct a mind him(her), to give him(her) soul.

- Where will we do it? - he(she) was saying M to his(her,your) erastes - the machines will reject our request.
- there is a center of androgénesis nearby to the platform, completely automatically but I believe that it(he) can be manipulated manually.
A voice besides them, soft and that was unfusing calmness spoke.
-Déjenme to serve them, I will be his(her,your) IT contact with the computer of the center - said Nimis - otherwise the opposite they will refuse the access to them. But the process is an algorithm that nobody can do manually.
- I am thinking about dealing since(as,like) it(he,she) should hacerse - he(she) said L that wanted to conceive close to M. was wishing one of the things that mas was despising of the life. It(he) was subordinated now to the same mission of the bacteria and of the mildew of the soil. L was a primitive(original) animal and luminous mas in was subordinating himself to this primary desire.
M and L they were surprised but trusted in the intentions of the machine. They it was not also possible to refuse.
To change - said Nimis - you. He(she) will construct something me.
I will do it - he(she) said L.
Then L and M intended for the center of androgénesis. They were taking a few minuscule capsules, carrying a sample germinal of each one.
Already in the center Nimis I connect to the computer, it manipulating achievement to suspend his(her,your) mechanisms of protection, a synthetic voice spoke to them:
" They will be present at the process, which will last some hours, welcome - he(she) said the cheated computer of the center of reproduction to M and to L - android Nimis, deliver the samples of sperms ".

The androide Nimis delivered the samples and sat down near M and L, the three opposite to the screens and equipments(teams) of communication of the computer. To the center there was a bucket that was the three-dimensional screen of the microscope 3D where they would see the whole procedure.
- now you must lead the process - Nimis Said to L it(he,she) must turn one of the sperms into an ovum.
-L hesitated, it(he,she) could not do it like but tape-worm that to there be a logical and necessary way, in a few minutes he(she) supposed the technology(skill) and to speak.

A sound announced the beginning of the long process of androgénesis.
- examine the gametes.
- in the sample of the client L there are 34 000 viable sperms - he(she) said the computer obeying - the genetic screening begins of each one of them.
In the sample of M there are 25 000 and his(her,your) genetic screening is for 12 % of the sample.
On the screen 3D one saw how every sperm was separated microscopically by chemical microforceps.
On the screens one saw brief the genetic complete sequence of every genome, in every sperm and his(her,your) respective profile of suitability.
- evaluate also defective genes or mutations; also the proteómica and epigenéticamente every gene and his(her,your) potential contribution to the phenotype of the embryo - I order(arrange) L.

- the valuation of the chromosomes And, in view of the level of artificial genes that they contain, already it(he,she) was in our base of information - he(she) added the computer - and they do not contain, for his(her,your) artificial nature, any defective gene.
- at this moment this moment we will realize the evaluation of defective, semidefective and neutral genes - said the androide Nimis.
- What level of elimination of sperms do they wish? - he(she) said the computer-. We recommend an elimination of 90 %, remember that while more rigorous it is his(her,your) screening in this level the possibilities diminish in the following tests(proofs) of compatibility.
The machineries eliminated to the defective sperms. This simple process carried out during milleniums by the natural selection, happened now pacifically in the laboratory in a few brief seconds. This technology(skill) had taken the human capacity to his(her,your) more extreme high places of suitability and in addition it(he,she) had reduced the size of the human chromosomes when generation eliminated after generation all the genes or sections of DNA that were not possessing useful information, turning out to be now the chromosome And the biggest of the human genome.
- Bueno - said the androide Nimis - already we reject 94 % of the sperms.
- Ahora - he(she) said L - do the selection of compatible couples(par).

- they have to fill before these questionnaires, in them there will be annotated what alelos or combinations they consider to be more desirable and less desirable which. They have to know that the metacorporación already answered for you 93 % of the questions, given his(her,your) responsibility in the vigilance of the genetic human suitability.
They can answer a total of 1 200 questions.

This questionnaire delayed a couple of hours. Ultimately it(he,she) began the choice(election) of the most suitable pairs(couples) of sperms.
The machines were comparing the genetic profiles of the sperms of each one, were taking the first one of the thousands of L and were predicting how it would be his(her,your) combination with each of the sperms of the sample of M.
The number of necessary calculations was immense to be able to predict the genetic profile of the combination and this way it was realized by each of the possible pairs(couples).
Trillions of different persons might be formed(trained) from the thousands of sperms to the hand and now there would be chosen which of them would deserve to be born. The number of different embryos was theoretically superior to that of atom existing in the whole universe.
In the calculation, every gene possesses a coefficient, in addition this one was modified according to the genomic environment by the one that was combined. The number of combinations for calculating took hours to the most powerful computer.
- already we have it - said the androide Nimis - how many artificial ova will make?
-9 - he(She) said L.

Of the laboratory of androgénesis ova were made from basal cells taken of samples of blood of the clients. First one was giving the size and the biochemical characteristics of the ovum and later the genetic information was eliminated by radiations, so that empty ova were made like containers. But the genetic material must be modified. To refill these empty ova

- we have sperms since does machine turn them into ova? - he(she) said M.
L I concentrate in thinking. A myriad of information they were crowding in his(her,your) head, disorganized and confused. Finally he(she) said from a fever.
- What genes do express in 19q13.4? - L remembered(reminded) a strange bibliographical event in which a group of brothers were producing ova instead of sperms, ova with tail. In spite of his(her,your) anatomical perfection these espermatozoas were loading cores(nucleuses) of ova, epigeneticamente spoken. They all had mutated the region 13.4 in the long arm of the chromosome 19.

- on the screen, tens of genes appeared. L I examine them. Finally I identify one that an ARN was producing, this it(he,she) had to be.
Neutralize it with a complementary probe. A this probe to one enzyme Dnmt2a and neutralize the enzimas Dnmt3b
Amazing it(he,she) had succeeded. A series of biochemical reactions in waterfall began to
To turn these sperms into ova, with the exception of 2 genes Igf2 and H19.
Tormented L observe that the espermatozoide were 99,8 % ova. But without these genes they might not conceive.

The immobility of the whole city was surrounding it.
Million beings had reproduced before and about him(it), only to them it(he) they was useless.